Best Natural GLP-1 Supplements (AMPK activators) & Pills: Glucomannan & Psyllium husk fiber for weight loss

Ana Shrum is a seasoned nutrition and wellness consultant with over a decade of experience, specializing in holistic, evidence-based weight management. She helps busy professionals improve metabolic health through practical strategies eg. boosting glp1 naturally for sustainable results.

Quick Summary

1). Best Overall: PhenQ. For best results, I recommend taking this supplement along with their protein meal replacement shake (contains Beta-glucan fiber from oats). Aim to replace at least one meal. For added boost, consider adding an affordable psyllium husk (poor man’s ozempic) to this combo, which can also be mixed with the meal replacement shake.

2) Best fiber (glucomannan) based GLP-1 supplement: HourGlass Fit (for women) and Hunter Burn (for men)

3). Best Berberine-based GLP-1 supplement: Blood Sugar Optimizer

4). Most affordable: Isabgol (psyllium husk, poor man’s ozempic)

5). Best probiotic based GLP-1 supplement: LeanBiome and Thrive myGLP

1). PhenQ + PhenQ Meal replacement Shake: Best Overall

As a nutrition and wellness coach for over a decade, I’ve guided hundreds of clients through their weight loss journeys. Recently, I’ve had remarkable success with a specific combination that seems to mimic many benefits of GLP-1 medications without the prescription or side effects.

What I’ve Found Works Best

My clients have had great results combining:

• PhenQ supplement (Nopal cactus fiber with alpha-lipoic acid, cysteine, ginseng, iodine )
• PhenQ Meal Replacement Shake
• Additional psyllium husk fiber

I started recommending this protocol after noticing how many clients struggled with appetite control and sustainable weight loss. The results have been impressive.

Why This Combination Works

From working with my clients, I’ve observed that this combination:

1. Significantly reduces cravings and hunger – Almost every client reports feeling fuller longer and experiencing fewer urges to snack between meals
2. Stabilizes energy levels – No more afternoon crashes that drive poor food choices
3. Supports metabolic health – Several clients have reported improved bloodwork numbers, particularly around glucose control
4. Creates sustainable habits – Unlike crash diets, this approach helps clients develop a healthier relationship with food

Client Success Stories

One client, lost 32 pounds over 4 months using this protocol while reporting that for the first time in her life, she wasn’t constantly thinking about food.

Mark, another client, had been struggling with pre-diabetes. After 3 months on this regimen, his fasting glucose improved significantly, and he shed 18 pounds without feeling deprived.

How I Recommend Taking It

For best results, I advise clients to:

1. Take PhenQ supplement as directed on the packaging
2. Replace one meal (usually breakfast or lunch) with the PhenQ shake
3. Optional: Add 2 tablespoons of psyllium husk in divided doses (with lots of water) to increase fiber intake throughout the day

For more tips on how to use psyllium husk (poor man’s ozempic) with an appetite suppressant/GLP-1 supplement like PhenQ and HourGlass Fit, read this post.

Many of my clients find this approach much more affordable and accessible than prescription GLP-1 medications, with fewer side effects and more educational value for the long term.

How PhenQ’s ingredients help in activating ampk and acting as natural glp 1 supplement:-

Alpha-Lacys Reset (Alpha Lipoic Acid + Cysteine) – Metabolism & Energy Control

• Alpha Lipoic Acid (ALA): Activates AMPK, the body’s energy regulator, helping burn calories, reduce fat storage, and improve insulin response—indirectly boosting GLP-1 activity.
• Cysteine: Supports insulin function and metabolism, which may further aid GLP-1 release.

Ginseng – Natural GLP-1 Enhancer

• Ginseng boosts GLP-1 levels and improves insulin response, helping regulate blood sugar and appetite.
• It also slows digestion, mimicking the appetite-suppressing effects of GLP-1-based medications.

InnoSlim – Metabolism & Blood Sugar Support

• A blend of Panax Notoginseng and Astragalus, InnoSlim activates AMPK, improving glucose metabolism and reducing fat storage.
• It also increases adiponectin, a hormone that works with GLP-1 to control hunger and blood sugar.

Nopal (Prickly Pear Cactus) – Fiber & Appetite Control

• Rich in fiber, Nopal naturally boosts GLP-1 by slowing digestion and carbohydrate absorption.
• It helps delay stomach emptying, promoting fullness and better appetite control.

2). HourGlass Fit (for women) and Hunter Burn (for men)

Review: Natural glucomannan based GLP-1 duos for powerful weight loss support

If you are looking for a fiber based natural GLP-1 supplement that acts as an OTC Ozempic alternative, HourGlass Fit (for women) and Hunter Burn (for men) can help mimic the effects of prescription Wegovy. These products use ingredients like glucomannan fiber (Konjac Root Extract) and essential vitamins to naturally boost metabolism and control appetite, working as a natural GLP-1 booster for weight loss. I rate them 4.2 out of 5 for their straightforward, effective approach.

This supplement is ideal for active individuals seeking a non-prescription weight management aid.

Pros:

• Natural ingredient blend containing glucomannan fiber
• Boosts appetite control & mood
• Easy to use

Cons:

• Results vary
• Not a standalone solution

Ingredients

• Vitamin B6 (as Pyridoxine 5-Phosphate) – 1.7 mg
  Supports metabolism and energy production, indirectly aiding GLP-1 pathways by helping the body efficiently use nutrients and reduce fatigue.

• Vitamin B12 (as Adenosylcobalamin) – 2.4 µg
  Essential for energy and red blood cell formation, while helping maintain a healthy metabolic rate that complements natural GLP-1–focused weight management.

• Chromium (as Chromium Picolinate) – 125 µg
  Helps regulate blood sugar levels and control cravings, aligning with GLP-1’s role in appetite suppression and improved insulin sensitivity.

• Zinc (as Citrate) – 8 mg
  Vital for immune function and metabolic processes, providing balanced support that can enhance overall health and indirectly benefit GLP-1 mechanisms.

• Vitamin B2 (as Riboflavin) – 1.1 mg
  Plays a key role in converting food into usable energy, supporting healthy fat metabolism and complementing GLP-1–driven appetite control.

• Konjac Root Extract (Standardized to 90% Glucomannan) – 3000 mg
  A soluble fiber that naturally boosts GLP-1 by slowing digestion, promoting fullness, and reducing calorie intake.

• Cayenne Pepper Extract (Capsimax®) – 100 mg
  Provides thermogenic capsaicinoids to increase metabolic rate and fat burning, which can further support the calorie-reducing effects of elevated GLP-1.

• Black Pepper Extract (Bioperine™) – 5 mg
  Enhances nutrient absorption, making the supplement’s GLP-1–supportive ingredients more efficient and effective.

• 5-HTP (Griffonia simplicifolia extract) – 150 mg
  Helps raise serotonin levels to reduce emotional eating and improve mood, working in tandem with GLP-1’s role in hunger regulation.

3). Blood Sugar Optimizer

Review: Comprehensive Natural blood sugar boost for weight loss control.

Blood Sugar Optimizer can help control your blood sugar and support weight loss. My clients use it because its powerful ingredients—like berberine, cinnamon extract, resveratrol (quercetin) and Gymnema Sylvestre—work as a natural GLP-1 booster to reduce cravings and balance insulin, much like a natural version of Ozempic or Wegovy. I rate it 4.2 out of 5 for its clear benefits and doctor’s formulation.

This supplement is ideal for anyone seeking a natural Ozempic alternative for blood sugar control and weight management.

Pros:

• Balances blood sugar naturally
• Reduces cravings effectively
• Acts as a natural GLP-1 support

Cons:

• Results can vary
• Not a complete solution alone

Blood Sugar Optimizer Ingredients

• Berberine
  Improves insulin sensitivity and glucose uptake in cells, often likened to metformin. By enhancing metabolic efficiency and reducing sugar production in the liver, it can indirectly boost GLP-1–like effects on blood sugar control.

• Gymnema Sylvestre Extract (75% Gymnemic Acids)
  Reduces sugar absorption and enhances insulin function. Its high concentration of gymnemic acids makes it a potent, natural ally for supporting GLP-1–mediated mechanisms in managing blood sugar.

• Alpha Lipoic Acid (NA-R Form)
  A bioavailable antioxidant that alleviates oxidative stress while boosting insulin sensitivity. By improving metabolic function, it helps maintain stable glucose levels, complementing natural GLP-1 pathways.

• Cinnamon Extract (CinSulin® + Cinnulin PF®)
  Known for potential blood sugar–lowering effects and heightened insulin sensitivity. These specialized extracts offer a safer form of cinnamon, aligning with GLP-1’s role in appetite and glucose control.

• Bitter Melon (Nepatica)
  Enhances glucose uptake and insulin secretion, promoting better blood sugar balance. Often used in natural diabetes support formulas, it can synergize with GLP-1’s actions on metabolic regulation.

• Fenugreek Seed (4:1 Extract; 50% Saponins)
  Slows sugar absorption and improves glucose tolerance via soluble fiber and saponins. By stabilizing blood sugar levels, it underpins the appetite-regulating and insulin-moderating benefits associated with natural GLP-1.

• Panax Ginseng (8% Ginsenosides)
  Known for moderate improvements in insulin sensitivity and blood sugar control. Its broad metabolic benefits can complement GLP-1–focused strategies for balanced energy and reduced cravings.

• Trans-Resveratrol (90% from Polygonum cuspidatum)
  A powerful antioxidant that supports cardiovascular and metabolic health, indirectly aiding glucose metabolism and potential GLP-1–like benefits.

• Banaba Leaf Extract (1.5% Corosolic Acid)
  Promotes healthy blood sugar levels by enhancing glucose uptake, aligning with natural GLP-1 mechanisms that regulate insulin release and appetite.

• Vanadyl Sulfate (20% Vanadium)
  May aid insulin sensitivity and glucose metabolism, offering another supportive pathway that works alongside GLP-1–oriented approaches to maintain healthy blood sugar.

4). Lemme Glp1 Daily

 

Review: Celebrity-endorsed daily formula supporting gentle metabolic momentum.

Lemme glp 1 Daily offers a user-friendly approach to natural weight management, helping promote appetite regulation, blood sugar balance, and metabolic support with its blend of Morosil™, Eriomin®, and Supresa® extracts. From my experience, my clients have found it moderately effective, worth about 3.8 out of 5, as it subtly supported daily energy and GLP-1–like benefits without drastic changes or jittery side effects.

Who should use this: Anyone seeking a gentle, celebrity-backed supplement aimed at glucose metabolism and overall metabolic support.

Pros
• Helps tame cravings without a harsh crash
• Contains notable ingredients for blood sugar balance
• User-friendly, once-daily routine

Cons
• Results may be gradual rather than immediate
• Premium pricing might be a barrier for some

Lemme glp 1 Daily’s ingredients (by Kourtney Kardashian)

• Morosil™ Red Orange Fruit Extract (Citrus sinensis) – 400 mg
  Standardized to 0.8% anthocyanins, this extract may aid weight management and metabolic health. By supporting healthy blood sugar levels and enhancing metabolism, it aligns with the appetite-regulating functions tied to GLP-1.

• Eriomin® Lemon Fruit Extract (Citrus limon) – 200 mg
  Standardized to 70% eriocitrin, known for its potent antioxidant properties and blood sugar support. Maintaining balanced glucose levels can help optimize the body’s natural GLP-1 response and potentially reduce cravings.

• Supresa® Saffron Extract (Crocus sativus, stigma) – 176.5 mg
  Standardized to 0.3% safranal, this ingredient may help control appetite and improve mood. By supporting a calmer, more controlled eating pattern, it complements GLP-1’s role in regulating satiety and encouraging steady food intake.

5).  Triquetra Health GLP-Activate

Review: Comprehensive GLP-1 support delivering balanced, synergy-driven metabolism

Triquetra Health GLP-Activate stands out as a potent, natural GLP-1 pill alternative by blending berberine (often called “nature’s Ozempic”), green tea extract, and curcumin to enhance AMPK activation, blood sugar control, and metabolic support, while also offering mild thermogenesis for a noticeable yet balanced approach to weight management; I’d rate it around 4 out of 5 for its thoughtful, research-backed ingredient profile that can curb cravings and support insulin sensitivity without overwhelming side effects.

Who should use this: Anyone seeking a natural, multifaceted approach to support healthy GLP-1 levels, improve insulin sensitivity, and aid weight control.

Pros
• Berberine for potent AMPK and GLP-1 activation
• Cinnamon and aloe for blood sugar balance and digestion
• Capsaicin analog (AXIVITE®) offers a gentle metabolic boost

Cons
• Slightly pricier than simpler berberine supplements
• Some may find capsaicin’s effects too warming
• Best results require consistent, long-term use

Triquetra Health GLP-Activate’s ingredients

• Berberine HCl (Berberis aristata root extract) – 195 mg
  Acts as “nature’s Ozempic” by activating AMPK, enhancing insulin sensitivity, and increasing GLP-1 secretion—essential for balanced blood sugar and appetite regulation.

• Green Tea Extract (Camellia sinensis leaf) – 165 mg
  Standardized to 50% EGCG, it supports fat metabolism, thermogenesis, and antioxidant defense, complementing GLP-1’s effects on weight management.

• Organic Ceylon Cinnamon (Cinnamomum verum bark) – 90 mg
  Helps stabilize blood sugar, supports healthy insulin function, and may boost GLP-1 release for improved metabolic control.

• Aloe Vera (Aloe barbadensis inner leaf gel, 200:1) – 42 mg
  Supports gut health and reduces inflammation, indirectly aiding GLP-1 activity and overall metabolic function.

• Curcumin C3 Complex® (Turmeric extract) – 42 mg
  Standardized to 95% curcuminoids, it helps regulate insulin, fights inflammation, and promotes metabolic health—all aligning with GLP-1 optimization.

• Taurine – 40 mg
  Contributes to energy metabolism, insulin sensitivity, and fat oxidation, reinforcing GLP-1’s role in balanced glucose control.

• AXIVITE® Phenylcapsaicin – 19 mg
  A capsaicin analog that boosts thermogenesis and helps regulate appetite, further supporting weight management via GLP-1 pathways.

• Boron (as Boron Glycinate) – 3 mg
  Enhances hormonal balance and metabolic function, aiding in overall energy and glucose regulation.

6). Lemme glp1 product line : Lemme Burn and Lemme Curb combo

Review: AMPK-powered daily burner fueling a charged-up metabolism, combined with decent cravings-control formula

This celebrity-endorsed AMPK-activating supplement feels like a solid way to boost metabolism, enhance fat oxidation, and increase energy through its synergistic blend of Actiponin®, Green Tea Extract, and B Vitamins. From my user perspective, I’d give it about 3.8 out of 5, noticing steady improvements in thermogenesis and weight management over time.

Part of the Lemme glp1 product line, Lemme Curb takes on cravings head-on with a Chromium, Bitter Melon, and Cinnamon-based formula, designed to maintain blood sugar balance, manage appetite, and encourage overall metabolic health. Personally, I rate this at 3.8 out of 5, seeing subtle but steady appetite control improvements.

Pros & Cons

• Pros:
  • Dual action on metabolism and cravings
  • Steady thermogenesis and energy boost without jitters
  • Known, research-backed ingredients in each formula
• Cons:
  • May take a few weeks for full effect
  • Can be pricey for some budgets
  • Requires consistent daily use for noticeable results

Lemme Burn (Metabolism + AMPK Activation) ingredients

• Vitamin B6 (Pyridoxal 5-Phosphate) – 5 mg
  Bolsters energy metabolism and aids fat oxidation, indirectly supporting a balanced metabolic state that can complement natural GLP-1 activity.

• Vitamin B12 (Methylcobalamin) – 500 mcg
  Helps drive energy production and metabolic function, giving an added boost that supports calorie burning and sustained vitality.

• Actiponin® (Gynostemma pentaphyllum) – 450 mg
  Activates AMPK (the “metabolic switch”), which helps enhance fat burning and weight management, aligning with GLP-1’s role in curbing appetite.

• Green Tea Extract (98% polyphenols, 50% EGCG) – 250 mg
  Increases thermogenesis and fat oxidation while protecting cells from oxidative stress, helping you maintain a faster metabolism.

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Lemme Curb (Glucose & Cravings Support ) ingredients

• Chromium (Chromium Picolinate) – 600 mcg
  Stabilizes blood sugar and reduces carb cravings, reinforcing GLP-1–like appetite control.

• Potassium (Potassium Chloride) – 100 mg
  Provides essential electrolytes that help maintain metabolic balance and support muscle function.

• Bitter Melon Extract (Momordica charantia) – 500 mg
  Aids blood sugar regulation and supports appetite control, building on GLP-1–focused strategies for healthy glucose metabolism.

• Organic Cinnamon Bark (Cinnamomum verum) – 150 mg
  Known for helping stabilize blood sugar and combat sweet cravings, complementing natural GLP-1 pathways.

• Greens Superfood Blend – 60 mg
  Offers antioxidants and fiber for improved digestion, nutrient support, and a well-rounded approach to metabolic health.

7). LeanBiome

Review: Probiotic-driven formula nurturing a healthy metabolism naturally

LeanBiome serves as a gentle, natural GLP-1 pill alternative by blending probiotic strains, prebiotic fiber, and green tea phytosome to bolster gut health, metabolic balance, and appetite regulation, though I’d give it about 3.6 out of 5 since the probiotic approach can take time for noticeable weight-loss effects compared to stronger OTC Ozempic–style or AMPK activators.

Who should use this: Anyone seeking a probiotic-based strategy to naturally support gut-driven weight management and GLP-1–like benefits.

LeanBiome ingredients

• Probiotic Strains

  • Lactobacillus gasseri (25 mg, 10 Billion CFU): Enhances gut health, metabolism, and weight management by supporting balanced digestion and potentially aiding GLP-1 pathways.
  • Lactobacillus rhamnosus (10 mg, 5 Billion CFU): May promote digestion and appetite regulation, further complementing natural GLP-1’s role in satiety.
  • Proprietary Probiotic Blend (10 mg, 5 Billion CFU): Contains Lactobacillus fermentum, Lactobacillus paracasei, Lactobacillus plantarum, Bifidobacterium bifidum, Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium breve—all crucial for optimizing the gut microbiome, which in turn supports GLP-1–linked metabolic and appetite benefits.

• Prebiotic Fiber

  • Inulin (from Chicory Root) – 200 mg: Feeds beneficial gut bacteria, potentially reinforcing GLP-1 secretion by improving digestion and helping manage appetite.

• Metabolism & Fat-Burning Ingredients

  • Green Tea Phytosome – 300 mg: Decaffeinated green tea extract bound to phospholipids, supporting fat metabolism, thermogenesis, and sustained energy—indirectly working with GLP-1 for weight management.
  • Sphaeranthus indicus – 300 mg: Traditionally utilized for metabolic support, potentially aiding in overall insulin sensitivity and appetite regulation.
  • Garcinia Mangostana (Pericarp) – 100 mg: Known as Mangosteen, may promote healthy weight loss, inflammation control, and metabolic function, contributing to an environment conducive to natural GLP-1 action.

8). Le-Vel Thrive myGLP

Review: Synergistic GLP-1 booster delivering balanced metabolic support.

Le-Vel Thrive myGLP glp-1 supplement offers an OTC Ozempic–style alternative that combines dihydroberberine, glucomannan, curcumin and other potent ingredients to naturally support blood sugar regulation, GLP-1 activation, and weight management.

From my experience, I’d rate this at 3.6 out of 5, as it subtly helps curb cravings, boost metabolism, and maintain satiety without overwhelming side effects, reminding me of other AMPK activators like Actiponin and classic fibers like psyllium and glucomannan.

Who should use this: Anyone wanting a natural glp-1 pill option for gentle appetite control and blood sugar balance similar to Wegovy or Ozempic benefits.

Pros & Cons

Pro:

Effective combination of GLP-1–supporting botanicals

Includes probiotic to aid digestion

Provides natural caffeine boost

Cons:

Higher price point than some alternatives

Results may be gradual, requiring consistent use

Might not suit sensitive caffeine users

Le-Vel Thrive myGLP (in the Context of Natural GLP-1 Support) ingredients

• Dihydroberberine
  A highly bioavailable form of berberine that regulates blood sugar and may enhance GLP-1 activation, making it a significant player in metabolic support.

• Gardenia Fruit Powder
  Traditionally aids metabolism and digestive health, supporting a balanced gut environment conducive to GLP-1 secretion.

• Ceylon Cinnamon
  Helps maintain stable blood sugar and insulin sensitivity, reinforcing the appetite-regulating functions linked to GLP-1.

• Turmeric Root Extract (95% Curcuminoids)
  Known for reducing inflammation and promoting metabolic health, indirectly optimizing GLP-1 pathways.

• Glucomannan
  A soluble fiber that slows digestion and promotes satiety, helping enhance natural GLP-1 secretion and reduce caloric intake.

• Red Ginseng (Panax Ginseng)
  May stimulate GLP-1 levels and improve insulin sensitivity, contributing to healthy appetite control.

• Natural Caffeine (from Green Tea)
  Boosts energy and thermogenesis, providing mild support for calorie expenditure alongside GLP-1’s appetite effects.

• Glutamine
  An amino acid that supports gut health and metabolism, indirectly aiding the environment for optimal GLP-1 function.

• Pea Extract
  Can help control appetite and assist in stabilizing blood sugar, complementing GLP-1’s role in glucose management.

• Citrus Aurantium Extract
  Often used for metabolic enhancement and fat oxidation, working in harmony with GLP-1 to support weight control.

• Cayenne Fruit Extract
  Sparks thermogenesis and improves digestion, further promoting metabolic activity.

• Black Pepper Extract (95% Piperine)
  Improves nutrient absorption and metabolism, maximizing the supplement’s overall effectiveness for GLP-1 benefits.

• Chlorogenic Acid (from Green Coffee)
  Assists in fat metabolism and blood sugar regulation, reinforcing GLP-1–like effects on glucose balance.

• Ginger Root Extract
  Supports digestion and metabolic health, contributing to a stable gut environment conducive to GLP-1 secretion.

• Bifidobacterium Lactis
  A probiotic that helps gut health and digestion, indirectly bolstering GLP-1 activity through a healthier microbiome.

• Magnesium (as Magnesium Citrate)
  Assists various metabolic processes, offering minor support for overall glucose and energy balance.

9). Bariatric Fusion GLP-ONE + Receptor Activator

Review: Gentle supplement combining metabolic synergy with anti-inflammatory support

Bariatric Fusion GLP-ONE + Receptor Activator provides a mild, natural GLP-1 support by combining copaiba extract (standardized to ß-caryophyllene) and xanthohumolone from hops for anti-inflammatory and glucose-regulating benefits; in my experience, I’d rate it about 3.5 out of 5, noting it offers subtle improvements in metabolic health and gut balance without being as potent as more expansive OTC Ozempic–like formulas.

Who should use this: Those seeking a gentle, anti-inflammatory boost that complements broader GLP-1–focused and metabolic strategies.

Bariatric Fusion GLP-ONE ingredients

• Copaiba Extract – 75 mg
  Derived from Copaifera officinalis (oleoresin), standardized to 10% ß-caryophyllene. This component provides anti-inflammatory and metabolic benefits, potentially promoting gut health and glucose regulation—all key factors in optimizing natural GLP-1 activity.

• Xanthohumolone – 8 mg
  Extracted from hops (Humulus lupulus) at >15% concentration. Known for its contributions to metabolic health, glucose control, and inflammation reduction, it supports weight management and insulin sensitivity, aligning with GLP-1–focused strategies for appetite and blood sugar regulation.

 

10). Herbalean GLPure

Review: Comprehensive metabolic blend spotlighting berberine’s natural potency.

Herbalean GLPure stands out as a potent natural GLP-1 pill alternative, blending berberine (“nature’s Ozempic”), bitter melon, and ginseng to help regulate blood sugar, activate AMPK, and subtly mimic OTC Ozempic benefits for weight loss; I’d rate it around 4.0 out of 5, finding it effective for appetite control and steady metabolic support without harsh side effects.

Who should use this: Anyone seeking a synergistic, nature-based formula to improve glucose metabolism and assist with Wegovy-style weight management.

Pros
• Robust lineup of GLP-1–supportive botanicals
• Chromium for cravings control and blood sugar stability
• BioPerine® to boost overall nutrient absorption

Cons
• May require consistent use for noticeable effects
• Some may find multiple ingredients potent on digestion
• Slightly higher price due to premium extracts

Herbalean GLPure ingredients

• Berberine HCl – 200 mg
  Dubbed “nature’s Ozempic,” berberine activates AMPK, boosts GLP-1 secretion, and improves insulin sensitivity for better blood sugar control.

• Turmeric Extract – 100 mg
  Contains curcuminoids that help reduce inflammation and support metabolic health, indirectly aiding GLP-1 function.

• Green Tea Extract (50% EGCG) – 100 mg
  Enhances fat oxidation, thermogenesis, and overall metabolism, reinforcing weight-management benefits alongside GLP-1.

• Gardenia Fruit Powder – 50 mg
  Traditionally used to support digestion and metabolism, complementing GLP-1’s role in glucose regulation.

• Bitter Melon Fruit Extract (5% Bitter Principles) – 30 mg
  Helps stabilize blood sugar and insulin function, potentially supporting GLP-1 activity for appetite control.

• Panax Ginseng (5% Total Ginsenosides) – 50 mg
  May stimulate GLP-1 secretion, improve insulin sensitivity, and help regulate appetite for balanced energy use.

• BioPerine® (Black Pepper Extract) – 5 mg
  Improves the absorption and bioavailability of other ingredients, maximizing their GLP-1–focused benefits.

• Chromium (Chromium Picolinate) – 500 mcg
  A key nutrient for glucose metabolism and cravings control, further supporting the appetite-regulating impact of GLP-1.

 

11). Calocurb

Review: Amarasate-infused satiety capsule for gentle, natural appetite control.

Calocurb delivers a convenient, natural GLP-1 pill–style approach by using Amarasate® from New Zealand hops to increase satiety hormones, curb appetite, and gently mimic OTC Ozempic benefits; I’d rate it around 3.9 out of 5, noticing steady hunger control and reduced snacking without major side effects.

Who should use this: Those looking for a plant-based, stimulant-free solution to tackle cravings and manage weight naturally.

Pros
• Plant-derived extract that specifically targets hunger hormones
• Delayed-release capsules for a smoother effect
• Mild, consistent appetite suppression

Cons
• Best results may require regular, ongoing use
• Some users may desire stronger metabolic or AMPK activation
• Higher cost compared to simpler fiber-based options like psyllium

Calocurb ingredients

• Amarasate® Extract (New Zealand Hops Flower) – 250 mg
  Derived from Humulus lupulus, this proprietary extract stimulates the release of satiety hormones like GLP-1, helping to curb appetite naturally and reduce snacking.

• Other Ingredients (Canola oil, Rosemary leaf extract, Delayed-release vegetarian capsules)
  Formulated to support and protect the active compound, ensuring effective delivery and absorption for enhanced appetite control and potential weight-management benefits.

12). Arrae MB-1 (Metabolic Burn)

Review: Gentle metabolic boost combining chromium, probiotic, and botanicals.

Arrae MB-1 (Metabolic Burn) takes a multi-pronged approach to natural GLP-1 pill–style weight management by blending African Mango IGOB131®, Cissus Leaf Extract, and a probiotic to help balance blood sugar, enhance metabolism, and lightly mimic the effects of OTC Ozempic or AMPK activators; however, I’d rate it around 3.2 out of 5, as the thermogenic benefits aren’t as prominent as some stronger wegovy alternatives or fiber-centric formulas like psyllium or glucomannan.

Who should use this: Individuals seeking a mild, all-in-one formula that supports appetite control, digestive wellness, and a modest metabolic lift.

Pros
• Solid mix of thermogenics and a beneficial probiotic
• Chromium supports healthy blood sugar levels and cravings
• Convenient capsule format for daily use

Cons
• Effects may be too subtle for some users
• Less potent than other AMPK-focused or high-fiber supplements
• May take consistent use to notice weight-loss impact

Arrae MB-1 ingredients

• Vitamin B6 (as Pyridoxal 5-Phosphate) – 5 mg
  Aids in energy metabolism, hormonal balance, and overall metabolic support, indirectly helping the body maintain stable glucose levels that complement GLP-1–driven satiety.

• Chromium (as Chromium Picolinate) – 500 mcg
  Regulates blood sugar and reduces cravings, reinforcing GLP-1’s role in hunger suppression and healthy insulin sensitivity.

• Proprietary Blend – 895 mg

  • Green Tea Extract: Contributes antioxidants and natural caffeine, boosting metabolism and supporting calorie burn alongside GLP-1’s appetite-regulating effects.
  • African Mango Seed Extract (IGOB131®): May help curb appetite, promoting healthy metabolism and complementing GLP-1’s role in managing caloric intake.
  • Cissus Leaf Extract (CQR-300®): Supports inflammation reduction and may enhance weight management, aiding in a more efficient metabolic environment for GLP-1.
  • Grains of Paradise Seed Extract: A thermogenic component that can elevate calorie expenditure and fat metabolism, working synergistically with GLP-1’s satiety signals.

• Bifidobacterium lactis B420 – 10 Billion CFU
  A gut-friendly probiotic strain that aids digestion and may improve weight management, fostering an intestinal environment that can amplify GLP-1 secretion and action.

13). Colonbroom Premium

Review: Fiber-first formula fueling gentle gut and metabolic synergy

Colonbroom Premium harnesses the power of psyllium husk, often referred to as “poor man’s ozempic” and essential vitamins to improve gut health, regulate digestion, and aid weight management through appetite control and mild blood sugar support—though I’d personally rate it around 3 out of 5 for effectiveness, since it offers steady but not dramatic results compared to stronger OTC Ozempic alternatives.

Who should use this: Anyone looking for a gentle, fiber-centric approach to appetite management and improved digestive regularity.

Pros

• High-fiber psyllium for healthy digestion and satiety
• Includes thermogenic Capsimax® for metabolism support
• Energy-boosting vitamins like B6 and B12

 

Cons

• Results may be subtle for serious weight-loss goals
• Some may find regular fiber dosing inconvenient
• Mild benefits compared to stronger AMPK-activators

Colonbroom Premium ingredients

• Psyllium Seed Husk Powder – 3.6g
  High in soluble fiber, it slows digestion, helps control appetite, and may increase GLP-1 secretion—assisting in natural satiety and better blood sugar regulation.

• L-Carnitine Tartrate – 1g
  Aids fat metabolism and energy production, supporting the body’s overall metabolic efficiency, which works in tandem with GLP-1–driven appetite control.

• Capsimax® Cayenne Fruit Extract – 50mg
  Offers thermogenic benefits and enhances digestion, aligning with the calorie-burning aspect of natural GLP-1–based weight management.

• Vitamin B6 (Pyridoxine HC) – 50mg
  Supports energy metabolism and brain function, maintaining overall energy balance that complements GLP-1–inspired strategies.

• Vitamin B12 (Cyanocobalamin) – 20mcg
  Crucial for red blood cell formation and energy production, aiding in steady metabolic function and supporting GLP-1’s role in hunger regulation.

• Iron – 1mg
  Assists with oxygen transport and energy levels, contributing to a well-rounded metabolic foundation.

• Chromium (Chromium Picolinate) – 200mcg
  Helps manage blood sugar and cravings, reinforcing GLP-1’s effect on insulin sensitivity and appetite suppression.

• Sodium (Pink Himalayan Sea Salt) – 59mg
  Provides essential electrolytes to support digestion and hydration, indirectly fostering a healthier metabolic environment where GLP-1 can function effectively.

14). PGX Daily

Review: Konjac-based daily fiber for gentle GLP-1 support

PGX Daily functions like a gentle, OTC Ozempic alternative for those seeking natural GLP-1 pills with glucomannan–based support, using a special PolyGlycopleX blend of konjac, sodium alginate, and xanthan gum to curb cravings, stabilize blood sugar, and aid weight management, though personally I’d rate it at around 3 out of 5 due to its gradual, fiber-focused effects compared to stronger AMPK activators.

Who should use this: Individuals wanting a simple, fiber-driven approach to appetite regulation and satiety.

PGX Daily ingredients

• PGX (PolyGlycopleX) – 750 mg
  Combines konjac (Amorphophallus konjac) root, sodium alginate, and xanthan gum to create a highly viscous fiber matrix. This slows digestion, promotes satiety, and may enhance GLP-1 secretion—helping control cravings and stabilize blood sugar levels.

• Medium-Chain Triglycerides (MCTs) – 600 mg
  Provide a quick energy source and support healthy metabolism, complementing the appetite-modulating effects of GLP-1 by discouraging sudden hunger spikes.